diff --git a/drivers/serial/uart_nrfx_uarte.c b/drivers/serial/uart_nrfx_uarte.c
index 08cb236b918..ffb090ca16f 100644
--- a/drivers/serial/uart_nrfx_uarte.c
+++ b/drivers/serial/uart_nrfx_uarte.c
@@ -127,27 +127,6 @@ LOG_MODULE_REGISTER(uart_nrfx_uarte, CONFIG_UART_LOG_LEVEL);
  */
 #define UARTE_ANY_HIGH_SPEED (UARTE_FOR_EACH_INSTANCE(INSTANCE_IS_HIGH_SPEED, (||), (0)))
 
-#define UARTE_PINS_CROSS_DOMAIN(unused, prefix, idx, _)			\
-	COND_CODE_1(DT_NODE_HAS_STATUS_OKAY(UARTE(prefix##idx)),	\
-		   (UARTE_PROP(idx, cross_domain_pins_supported)),	\
-		   (0))
-
-#if UARTE_FOR_EACH_INSTANCE(UARTE_PINS_CROSS_DOMAIN, (||), (0))
-#include <hal/nrf_gpio.h>
-/* Certain UARTE instances support usage of cross domain pins in form of dedicated pins on
- * a port different from the default one.
- */
-#define UARTE_CROSS_DOMAIN_PINS_SUPPORTED 1
-#endif
-
-#if UARTE_CROSS_DOMAIN_PINS_SUPPORTED && defined(CONFIG_NRF_SYS_EVENT)
-#include <nrf_sys_event.h>
-/* To use cross domain pins, constant latency mode needs to be applied, which is
- * handled via nrf_sys_event requests.
- */
-#define UARTE_CROSS_DOMAIN_PINS_HANDLE 1
-#endif
-
 #ifdef UARTE_ANY_CACHE
 /* uart120 instance does not retain BAUDRATE register when ENABLE=0. When this instance
  * is used then baudrate must be set after enabling the peripheral and not before.
@@ -415,10 +394,6 @@ struct uarte_nrfx_config {
 #endif
 	uint8_t *poll_out_byte;
 	uint8_t *poll_in_byte;
-#if UARTE_CROSS_DOMAIN_PINS_SUPPORTED
-	bool cross_domain;
-	int8_t default_port;
-#endif
 };
 
 /* Using Macro instead of static inline function to handle NO_OPTIMIZATIONS case
@@ -493,32 +468,6 @@ static void uarte_disable_locked(const struct device *dev, uint32_t dis_mask)
 	(void)pinctrl_apply_state(config->pcfg, PINCTRL_STATE_SLEEP);
 }
 
-#if UARTE_CROSS_DOMAIN_PINS_SUPPORTED
-static bool uarte_has_cross_domain_connection(const struct uarte_nrfx_config *config)
-{
-	const struct pinctrl_dev_config *pcfg = config->pcfg;
-	const struct pinctrl_state *state;
-	int ret;
-
-	ret = pinctrl_lookup_state(pcfg, PINCTRL_STATE_DEFAULT, &state);
-	if (ret < 0) {
-		LOG_ERR("Unable to read pin state");
-		return false;
-	}
-
-	for (uint8_t i = 0U; i < state->pin_cnt; i++) {
-		uint32_t pin = NRF_GET_PIN(state->pins[i]);
-
-		if ((pin != NRF_PIN_DISCONNECTED) &&
-		    (nrf_gpio_pin_port_number_extract(&pin) != config->default_port)) {
-			return true;
-		}
-	}
-
-	return false;
-}
-#endif
-
 #if defined(UARTE_ANY_NONE_ASYNC) && !defined(CONFIG_UART_NRFX_UARTE_NO_IRQ)
 /**
  * @brief Interrupt service routine.
@@ -805,20 +754,6 @@ static void uarte_periph_enable(const struct device *dev)
 	(void)pinctrl_apply_state(config->pcfg, PINCTRL_STATE_DEFAULT);
 	nrf_uarte_enable(uarte);
 
-#if UARTE_CROSS_DOMAIN_PINS_SUPPORTED
-	if (config->cross_domain && uarte_has_cross_domain_connection(config)) {
-#if UARTE_CROSS_DOMAIN_PINS_HANDLE
-		int err;
-
-		err = nrf_sys_event_request_global_constlat();
-		(void)err;
-		__ASSERT_NO_MSG(err >= 0);
-#else
-		__ASSERT(false, "NRF_SYS_EVENT needs to be enabled to use cross domain pins.\n");
-#endif
-	}
-#endif
-
 #if UARTE_BAUDRATE_RETENTION_WORKAROUND
 	if (config->flags & UARTE_CFG_FLAG_VOLATILE_BAUDRATE) {
 		nrf_uarte_baudrate_set(uarte,
@@ -3175,20 +3110,6 @@ static void uarte_pm_suspend(const struct device *dev)
 		wait_for_tx_stopped(dev);
 	}
 
-#if UARTE_CROSS_DOMAIN_PINS_SUPPORTED
-	if (cfg->cross_domain && uarte_has_cross_domain_connection(cfg)) {
-#if UARTE_CROSS_DOMAIN_PINS_HANDLE
-		int err;
-
-		err = nrf_sys_event_release_global_constlat();
-		(void)err;
-		__ASSERT_NO_MSG(err >= 0);
-#else
-		__ASSERT(false, "NRF_SYS_EVENT needs to be enabled to use cross domain pins.\n");
-#endif
-	}
-#endif
-
 	(void)pinctrl_apply_state(cfg->pcfg, PINCTRL_STATE_SLEEP);
 	nrf_uarte_disable(uarte);
 }
@@ -3518,11 +3439,6 @@ static int uarte_instance_deinit(const struct device *dev)
 		IF_ENABLED(CONFIG_UART_##idx##_NRF_HW_ASYNC,		       \
 			(.timer = NRFX_TIMER_INSTANCE(			       \
 				CONFIG_UART_##idx##_NRF_HW_ASYNC_TIMER),))     \
-		IF_ENABLED(UARTE_PINS_CROSS_DOMAIN(_, /*empty*/, idx, _),      \
-			(.cross_domain = true,				       \
-			 .default_port =				       \
-				DT_PROP_OR(DT_PHANDLE(UARTE(idx),	       \
-					default_gpio_port), port, -1),))       \
 	};								       \
 	UARTE_DIRECT_ISR_DECLARE(idx)					       \
 	static int uarte_##idx##_init(const struct device *dev)		       \
diff --git a/drivers/spi/spi_nrfx_spim.c b/drivers/spi/spi_nrfx_spim.c
index 44451be58bc..390682260c8 100644
--- a/drivers/spi/spi_nrfx_spim.c
+++ b/drivers/spi/spi_nrfx_spim.c
@@ -54,28 +54,6 @@ LOG_MODULE_REGISTER(spi_nrfx_spim, CONFIG_SPI_LOG_LEVEL);
 #define SPIM_FOR_EACH_INSTANCE(f, sep, off_code, ...) \
 	NRFX_FOREACH_PRESENT(SPIM, f, sep, off_code, __VA_ARGS__)
 
-#define SPIM_PINS_CROSS_DOMAIN(unused, prefix, idx, _)			\
-	COND_CODE_1(DT_NODE_HAS_STATUS_OKAY(SPIM(prefix##idx)),		\
-		   (SPIM_PROP(idx, cross_domain_pins_supported)),	\
-		   (0))
-
-#if NRFX_FOREACH_PRESENT(SPIM, SPIM_PINS_CROSS_DOMAIN, (||), (0))
-#include <hal/nrf_gpio.h>
-/* Certain SPIM instances support usage of cross domain pins in form of dedicated pins on
- * a port different from the default one.
- */
-#define SPIM_CROSS_DOMAIN_SUPPORTED 1
-#endif
-
-#if SPIM_CROSS_DOMAIN_SUPPORTED && defined(CONFIG_NRF_SYS_EVENT)
-#include <nrf_sys_event.h>
-/* To use cross domain pins, constant latency mode needs to be applied, which is
- * handled via nrf_sys_event requests.
- */
-#define SPIM_CROSS_DOMAIN_PINS_HANDLE 1
-#endif
-
-
 struct spi_nrfx_data {
 	struct spi_context ctx;
 	const struct device *dev;
@@ -105,41 +83,11 @@ struct spi_nrfx_config {
 #endif
 	uint32_t wake_pin;
 	nrfx_gpiote_t wake_gpiote;
-#if SPIM_CROSS_DOMAIN_SUPPORTED
-	bool cross_domain;
-	int8_t default_port;
-#endif
 	void *mem_reg;
 };
 
 static void event_handler(const nrfx_spim_evt_t *p_event, void *p_context);
 
-#if SPIM_CROSS_DOMAIN_SUPPORTED
-static bool spim_has_cross_domain_connection(const struct spi_nrfx_config *config)
-{
-	const struct pinctrl_dev_config *pcfg = config->pcfg;
-	const struct pinctrl_state *state;
-	int ret;
-
-	ret = pinctrl_lookup_state(pcfg, PINCTRL_STATE_DEFAULT, &state);
-	if (ret < 0) {
-		LOG_ERR("Unable to read pin state");
-		return false;
-	}
-
-	for (uint8_t i = 0U; i < state->pin_cnt; i++) {
-		uint32_t pin = NRF_GET_PIN(state->pins[i]);
-
-		if ((pin != NRF_PIN_DISCONNECTED) &&
-		    (nrf_gpio_pin_port_number_extract(&pin) != config->default_port)) {
-			return true;
-		}
-	}
-
-	return false;
-}
-#endif
-
 static inline void finalize_spi_transaction(const struct device *dev, bool deactivate_cs)
 {
 	struct spi_nrfx_data *dev_data = dev->data;
@@ -686,20 +634,6 @@ static int spim_resume(const struct device *dev)
 		return -EAGAIN;
 	}
 
-#if SPIM_CROSS_DOMAIN_SUPPORTED
-	if (dev_config->cross_domain && spim_has_cross_domain_connection(dev_config)) {
-#if SPIM_CROSS_DOMAIN_PINS_HANDLE
-		int err;
-
-		err = nrf_sys_event_request_global_constlat();
-		(void)err;
-		__ASSERT_NO_MSG(err >= 0);
-#else
-		__ASSERT(false, "NRF_SYS_EVENT needs to be enabled to use cross domain pins.\n");
-#endif
-	}
-#endif
-
 	return 0;
 }
 
@@ -715,20 +649,6 @@ static void spim_suspend(const struct device *dev)
 
 	spi_context_cs_put_all(&dev_data->ctx);
 
-#if SPIM_CROSS_DOMAIN_SUPPORTED
-	if (dev_config->cross_domain && spim_has_cross_domain_connection(dev_config)) {
-#if SPIM_CROSS_DOMAIN_PINS_HANDLE
-		int err;
-
-		err = nrf_sys_event_release_global_constlat();
-		(void)err;
-		__ASSERT_NO_MSG(err >= 0);
-#else
-		__ASSERT(false, "NRF_SYS_EVENT needs to be enabled to use cross domain pins.\n");
-#endif
-	}
-#endif
-
 	(void)pinctrl_apply_state(dev_config->pcfg, PINCTRL_STATE_SLEEP);
 }
 
@@ -866,11 +786,6 @@ static int spi_nrfx_deinit(const struct device *dev)
 		.wake_pin = NRF_DT_GPIOS_TO_PSEL_OR(SPIM(idx), wake_gpios,     \
 						    WAKE_PIN_NOT_USED),	       \
 		.wake_gpiote = WAKE_GPIOTE_INSTANCE(SPIM(idx)),		       \
-		IF_ENABLED(SPIM_PINS_CROSS_DOMAIN(_, /*empty*/, idx, _),       \
-			(.cross_domain = true,				       \
-			 .default_port =				       \
-				DT_PROP_OR(DT_PHANDLE(SPIM(idx),	       \
-					default_gpio_port), port, -1),))       \
 		.mem_reg = DMM_DEV_TO_REG(SPIM(idx)),			       \
 	};								       \
 	BUILD_ASSERT(!SPIM_HAS_PROP(idx, wake_gpios) ||			       \
diff --git a/drivers/spi/spi_nrfx_spis.c b/drivers/spi/spi_nrfx_spis.c
index 4d1a9070c1a..0861ed3c2f5 100644
--- a/drivers/spi/spi_nrfx_spis.c
+++ b/drivers/spi/spi_nrfx_spis.c
@@ -32,27 +32,6 @@ LOG_MODULE_REGISTER(spi_nrfx_spis, CONFIG_SPI_LOG_LEVEL);
 #define SPIS_PROP(idx, prop) DT_PROP(SPIS(idx), prop)
 #define SPIS_HAS_PROP(idx, prop) DT_NODE_HAS_PROP(SPIS(idx), prop)
 
-#define SPIS_PINS_CROSS_DOMAIN(unused, prefix, idx, _)			\
-	COND_CODE_1(DT_NODE_HAS_STATUS_OKAY(SPIS(prefix##idx)),		\
-		   (SPIS_PROP(idx, cross_domain_pins_supported)),	\
-		   (0))
-
-#if NRFX_FOREACH_PRESENT(SPIS, SPIS_PINS_CROSS_DOMAIN, (||), (0))
-#include <hal/nrf_gpio.h>
-/* Certain SPIM instances support usage of cross domain pins in form of dedicated pins on
- * a port different from the default one.
- */
-#define SPIS_CROSS_DOMAIN_SUPPORTED 1
-#endif
-
-#if SPIS_CROSS_DOMAIN_SUPPORTED && defined(CONFIG_NRF_SYS_EVENT)
-#include <nrf_sys_event.h>
-/* To use cross domain pins, constant latency mode needs to be applied, which is
- * handled via nrf_sys_event requests.
- */
-#define SPIS_CROSS_DOMAIN_PINS_HANDLE 1
-#endif
-
 struct spi_nrfx_data {
 	struct spi_context ctx;
 	const struct device *dev;
@@ -72,38 +51,8 @@ struct spi_nrfx_config {
 	const struct pinctrl_dev_config *pcfg;
 	struct gpio_dt_spec wake_gpio;
 	void *mem_reg;
-#if SPIS_CROSS_DOMAIN_SUPPORTED
-	bool cross_domain;
-	int8_t default_port;
-#endif
 };
 
-#if SPIS_CROSS_DOMAIN_SUPPORTED
-static bool spis_has_cross_domain_connection(const struct spi_nrfx_config *config)
-{
-	const struct pinctrl_dev_config *pcfg = config->pcfg;
-	const struct pinctrl_state *state;
-	int ret;
-
-	ret = pinctrl_lookup_state(pcfg, PINCTRL_STATE_DEFAULT, &state);
-	if (ret < 0) {
-		LOG_ERR("Unable to read pin state");
-		return false;
-	}
-
-	for (uint8_t i = 0U; i < state->pin_cnt; i++) {
-		uint32_t pin = NRF_GET_PIN(state->pins[i]);
-
-		if ((pin != NRF_PIN_DISCONNECTED) &&
-		    (nrf_gpio_pin_port_number_extract(&pin) != config->default_port)) {
-			return true;
-		}
-	}
-
-	return false;
-}
-#endif
-
 static inline nrf_spis_mode_t get_nrf_spis_mode(uint16_t operation)
 {
 	if (SPI_MODE_GET(operation) & SPI_MODE_CPOL) {
@@ -423,20 +372,6 @@ static void spi_nrfx_suspend(const struct device *dev)
 		nrf_spis_disable(dev_config->spis.p_reg);
 	}
 
-#if SPIS_CROSS_DOMAIN_SUPPORTED
-	if (dev_config->cross_domain && spis_has_cross_domain_connection(dev_config)) {
-#if SPIS_CROSS_DOMAIN_PINS_HANDLE
-		int err;
-
-		err = nrf_sys_event_release_global_constlat();
-		(void)err;
-		__ASSERT_NO_MSG(err >= 0);
-#else
-		__ASSERT(false, "NRF_SYS_EVENT needs to be enabled to use cross domain pins.\n");
-#endif
-	}
-#endif
-
 	(void)pinctrl_apply_state(dev_config->pcfg, PINCTRL_STATE_SLEEP);
 }
 
@@ -446,20 +381,6 @@ static void spi_nrfx_resume(const struct device *dev)
 
 	(void)pinctrl_apply_state(dev_config->pcfg, PINCTRL_STATE_DEFAULT);
 
-#if SPIS_CROSS_DOMAIN_SUPPORTED
-	if (dev_config->cross_domain && spis_has_cross_domain_connection(dev_config)) {
-#if SPIS_CROSS_DOMAIN_PINS_HANDLE
-		int err;
-
-		err = nrf_sys_event_request_global_constlat();
-		(void)err;
-		__ASSERT_NO_MSG(err >= 0);
-#else
-		__ASSERT(false, "NRF_SYS_EVENT needs to be enabled to use cross domain pins.\n");
-#endif
-	}
-#endif
-
 	if (dev_config->wake_gpio.port == NULL) {
 		nrf_spis_enable(dev_config->spis.p_reg);
 	}
@@ -578,11 +499,6 @@ static int spi_nrfx_init(const struct device *dev)
 		.max_buf_len = BIT_MASK(SPIS_PROP(idx, easydma_maxcnt_bits)),  \
 		.wake_gpio = GPIO_DT_SPEC_GET_OR(SPIS(idx), wake_gpios, {0}),  \
 		.mem_reg = DMM_DEV_TO_REG(SPIS(idx)),			       \
-		IF_ENABLED(SPIS_PINS_CROSS_DOMAIN(_, /*empty*/, idx, _),       \
-			(.cross_domain = true,				       \
-			 .default_port =				       \
-				DT_PROP_OR(DT_PHANDLE(SPIS(idx),	       \
-					default_gpio_port), port, -1),))       \
 	};								       \
 	BUILD_ASSERT(!DT_NODE_HAS_PROP(SPIS(idx), wake_gpios) ||	       \
 		     !(DT_GPIO_FLAGS(SPIS(idx), wake_gpios) & GPIO_ACTIVE_LOW),\
diff --git a/dts/bindings/spi/nordic,nrf-spi-common.yaml b/dts/bindings/spi/nordic,nrf-spi-common.yaml
index e76d785b2f4..dc81950aed3 100644
--- a/dts/bindings/spi/nordic,nrf-spi-common.yaml
+++ b/dts/bindings/spi/nordic,nrf-spi-common.yaml
@@ -61,13 +61,3 @@ properties:
         and SPI master again keeps the line in the low state
       Please note that the line must be configured and properly handled on
       both sides for the mechanism to work correctly.
-
-  default-gpio-port:
-    type: phandle
-    description: |
-      SPI default GPIO port.
-
-  cross-domain-pins-supported:
-    type: boolean
-    description: |
-      SPI allows usage of cross domain pins with constant latency mode required.
diff --git a/dts/vendor/nordic/nrf54l_05_10_15.dtsi b/dts/vendor/nordic/nrf54l_05_10_15.dtsi
index 1cc8314aecc..5a4854440b6 100644
--- a/dts/vendor/nordic/nrf54l_05_10_15.dtsi
+++ b/dts/vendor/nordic/nrf54l_05_10_15.dtsi
@@ -315,8 +315,6 @@
 				rx-delay-supported;
 				rx-delay = <1>;
 				status = "disabled";
-				default-gpio-port = <&gpio1>;
-				cross-domain-pins-supported;
 			};
 
 			uart20: uart@c6000 {
@@ -326,8 +324,6 @@
 				status = "disabled";
 				endtx-stoptx-supported;
 				frame-timeout-supported;
-				default-gpio-port = <&gpio1>;
-				cross-domain-pins-supported;
 			};
 
 			i2c21: i2c@c7000 {
@@ -358,8 +354,6 @@
 				rx-delay-supported;
 				rx-delay = <1>;
 				status = "disabled";
-				default-gpio-port = <&gpio1>;
-				cross-domain-pins-supported;
 			};
 
 			uart21: uart@c7000 {
@@ -369,8 +363,6 @@
 				status = "disabled";
 				endtx-stoptx-supported;
 				frame-timeout-supported;
-				default-gpio-port = <&gpio1>;
-				cross-domain-pins-supported;
 			};
 
 			i2c22: i2c@c8000 {
diff --git a/tests/drivers/spi/spi_controller_peripheral/testcase.yaml b/tests/drivers/spi/spi_controller_peripheral/testcase.yaml
index a4581e54820..f2c10b6c716 100644
--- a/tests/drivers/spi/spi_controller_peripheral/testcase.yaml
+++ b/tests/drivers/spi/spi_controller_peripheral/testcase.yaml
@@ -109,6 +109,8 @@ tests:
     extra_configs:
       - CONFIG_TESTED_SPI_MODE=0
       - CONFIG_NRF_SYS_EVENT=y
+      - CONFIG_SOC_NRF_FORCE_CONSTLAT=y
+      - CONFIG_POWER_DOMAIN=n
     extra_args: DTC_OVERLAY_FILE="boards/nrf54l15dk_nrf54l15_cpuapp_cross_domain.overlay"
     platform_exclude:
       - nrf52840dk/nrf52840
diff --git a/tests/drivers/uart/uart_elementary/testcase.yaml b/tests/drivers/uart/uart_elementary/testcase.yaml
index cd25f46c141..b680e0f9642 100644
--- a/tests/drivers/uart/uart_elementary/testcase.yaml
+++ b/tests/drivers/uart/uart_elementary/testcase.yaml
@@ -100,3 +100,4 @@ tests:
     extra_args: DTC_OVERLAY_FILE="boards/nrf54l15dk_nrf54l15_cpuapp_cross_domain.overlay"
     extra_configs:
       - CONFIG_NRF_SYS_EVENT=y
+      - CONFIG_SOC_NRF_FORCE_CONSTLAT=y