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In recent years, a considerable interest has arisen in the development of noninvasive tools to improve early diagnosis, many new technical operation using a telecommunication network allow practitioners to perform in real time a relevant diagnosis. Because of the open environment of web\u2010based applications, their exploitation in medical field introduces many security concerns. In this article, we present DECOPREME (COllaborative PREcocious DEtection of Melanoma) a new project which allows practitioners to use telecommunication technologies to provide early diagnosis. We describe, after that, our proposed reversible watermarking method used for integrity verification, we also evaluate image visual quality after watermark embedding and the effectiveness of locating tampered regions. \u00a9 2009 Wiley Periodicals, Inc. 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