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However, this therapy has not been broadly implemented, partly because of the time required to create VR experiences tailored to a patient\u2019s specific trauma. To address this problem, this study proposes a system for exposure therapy that generates auditory VR using a Large Language Model (LLM) for natural language interaction. This system, built on LLM and an audio dataset, generates sounds matching user-provided themes and generates corresponding scenarios and coordinates. An experiment with clinicians using this system to generate auditory stimuli was conducted to assess the usability and therapeutic potential of the generated audio. The results indicated high usability and quality, requiring minimal adjustments for therapeutic applications. Notably, the clinicians generated sounds within the duration of a standard clinical session. However, challenges remain, particularly for complex themes, highlighting the need for further research to enhance usability and verify the system\u2019s clinical feasibility and efficacy.<\/jats:p>","DOI":"10.1145\/3723048","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T13:38:35Z","timestamp":1742391515000},"page":"1-28","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Development and Evaluation of an Auditory VR Generative System via\u00a0Natural Language Interaction to Aid Exposure Therapy for PTSD\u00a0Patients"],"prefix":"10.1145","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7385-7941","authenticated-orcid":false,"given":"Yuta","family":"Yamauchi","sequence":"first","affiliation":[{"name":"Graduate School Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-6302","authenticated-orcid":false,"given":"Keiko","family":"Ino","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-9452","authenticated-orcid":false,"given":"Masanori","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan, Institute of Medicine, University of Tsukuba, Tsukuba, Japan, and National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-5298","authenticated-orcid":false,"given":"Keiichi","family":"Zempo","sequence":"additional","affiliation":[{"name":"Institute of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"320","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"World Health Organization. 2023. 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