devenv.exe /DebugExe debug unitcase

ExecutableFile

Required. The path and file name of an .exe file.

If the .exe file is not found or does not exist, no warning or error is displayed and Visual Studio starts normally.

Any strings following the ExecutableFile parameter are passed to that file as arguments.

The following example opens the file MSTest.exe for debugging.

you can change the exe being debug property, like working directory.

http://msdn.microsoft.com/en-us/library/ms241274(VS.80).aspx