diff --git a/doc/src/sgml/func/func-admin.sgml b/doc/src/sgml/func/func-admin.sgml
index 6347fe60b0c4..6363084bc94e 100644
--- a/doc/src/sgml/func/func-admin.sgml
+++ b/doc/src/sgml/func/func-admin.sgml
@@ -1012,6 +1012,11 @@ postgres=# SELECT '0/0'::pg_lsn + pd.segment_number * ps.setting::int + :offset
     are also relevant for replication.
    </para>
 
+   <para>
+    Note that slot manipulation functions except <function>pg_drop_replication_slot</function>
+    cannot be used in single-user mode.
+   </para>
+
    <table id="functions-replication-table">
     <title>Replication Management Functions</title>
     <tgroup cols="1">
diff --git a/src/backend/replication/logical/logicalfuncs.c b/src/backend/replication/logical/logicalfuncs.c
index ca53caac2f2f..30877fdc3aba 100644
--- a/src/backend/replication/logical/logicalfuncs.c
+++ b/src/backend/replication/logical/logicalfuncs.c
@@ -113,6 +113,9 @@ pg_logical_slot_get_changes_guts(FunctionCallInfo fcinfo, bool confirm, bool bin
 	List	   *options = NIL;
 	DecodingOutputState *p;
 
+	/* Slot manipulation is not allowed in single-user mode */
+	CheckSlotIsInSingleUserMode();
+
 	CheckSlotPermissions();
 
 	CheckLogicalDecodingRequirements();
diff --git a/src/backend/replication/slot.c b/src/backend/replication/slot.c
index 8605776ad863..4ca1227cc943 100644
--- a/src/backend/replication/slot.c
+++ b/src/backend/replication/slot.c
@@ -653,7 +653,7 @@ ReplicationSlotAcquire(const char *name, bool nowait, bool error_if_invalid)
 	}
 	else
 	{
-		active_pid = MyProcPid;
+		s->active_pid = active_pid = MyProcPid;
 		ReplicationSlotSetInactiveSince(s, 0, true);
 	}
 	LWLockRelease(ReplicationSlotControlLock);
@@ -1529,6 +1529,18 @@ CheckSlotPermissions(void)
 						   "REPLICATION")));
 }
 
+/*
+ * Check whether the instance is in single-user mode.
+ */
+void
+CheckSlotIsInSingleUserMode(void)
+{
+	if (!IsUnderPostmaster)
+		ereport(ERROR,
+				(errcode(ERRCODE_OBJECT_NOT_IN_PREREQUISITE_STATE),
+				 errmsg("replication slots cannot be used in single-user mode")));
+}
+
 /*
  * Reserve WAL for the currently active slot.
  *
diff --git a/src/backend/replication/slotfuncs.c b/src/backend/replication/slotfuncs.c
index 69f4c6157c51..90fe63283a15 100644
--- a/src/backend/replication/slotfuncs.c
+++ b/src/backend/replication/slotfuncs.c
@@ -17,6 +17,7 @@
 #include "access/xlogrecovery.h"
 #include "access/xlogutils.h"
 #include "funcapi.h"
+#include "miscadmin.h"
 #include "replication/logical.h"
 #include "replication/slot.h"
 #include "replication/slotsync.h"
@@ -76,6 +77,9 @@ pg_create_physical_replication_slot(PG_FUNCTION_ARGS)
 	if (get_call_result_type(fcinfo, NULL, &tupdesc) != TYPEFUNC_COMPOSITE)
 		elog(ERROR, "return type must be a row type");
 
+	/* Slot manipulation is not allowed in single-user mode */
+	CheckSlotIsInSingleUserMode();
+
 	CheckSlotPermissions();
 
 	CheckSlotRequirements();
@@ -182,6 +186,9 @@ pg_create_logical_replication_slot(PG_FUNCTION_ARGS)
 	if (get_call_result_type(fcinfo, NULL, &tupdesc) != TYPEFUNC_COMPOSITE)
 		elog(ERROR, "return type must be a row type");
 
+	/* Slot manipulation is not allowed in single-user mode */
+	CheckSlotIsInSingleUserMode();
+
 	CheckSlotPermissions();
 
 	CheckLogicalDecodingRequirements();
@@ -521,6 +528,9 @@ pg_replication_slot_advance(PG_FUNCTION_ARGS)
 
 	Assert(!MyReplicationSlot);
 
+	/* Slot manipulation is not allowed in single-user mode */
+	CheckSlotIsInSingleUserMode();
+
 	CheckSlotPermissions();
 
 	if (XLogRecPtrIsInvalid(moveto))
@@ -618,9 +628,13 @@ copy_replication_slot(FunctionCallInfo fcinfo, bool logical_slot)
 	TupleDesc	tupdesc;
 	HeapTuple	tuple;
 
+
 	if (get_call_result_type(fcinfo, NULL, &tupdesc) != TYPEFUNC_COMPOSITE)
 		elog(ERROR, "return type must be a row type");
 
+	/* Slot manipulation is not allowed in single-user mode */
+	CheckSlotIsInSingleUserMode();
+
 	CheckSlotPermissions();
 
 	if (logical_slot)
diff --git a/src/backend/utils/adt/pg_upgrade_support.c b/src/backend/utils/adt/pg_upgrade_support.c
index a4f8b4faa90d..337f705b34b6 100644
--- a/src/backend/utils/adt/pg_upgrade_support.c
+++ b/src/backend/utils/adt/pg_upgrade_support.c
@@ -296,6 +296,9 @@ binary_upgrade_logical_slot_has_caught_up(PG_FUNCTION_ARGS)
 	 */
 	Assert(has_rolreplication(GetUserId()));
 
+	/* Slot manipulation is not allowed in single-user mode */
+	CheckSlotIsInSingleUserMode();
+
 	slot_name = PG_GETARG_NAME(0);
 
 	/* Acquire the given slot */
diff --git a/src/include/replication/slot.h b/src/include/replication/slot.h
index e8fc342d1a96..b4d89760f964 100644
--- a/src/include/replication/slot.h
+++ b/src/include/replication/slot.h
@@ -342,6 +342,7 @@ extern void CheckPointReplicationSlots(bool is_shutdown);
 
 extern void CheckSlotRequirements(void);
 extern void CheckSlotPermissions(void);
+extern void CheckSlotIsInSingleUserMode(void);
 extern ReplicationSlotInvalidationCause
 			GetSlotInvalidationCause(const char *cause_name);
 extern const char *GetSlotInvalidationCauseName(ReplicationSlotInvalidationCause cause);
diff --git a/src/test/modules/test_misc/meson.build b/src/test/modules/test_misc/meson.build
index 9c50de7efb0f..08357d2f2e8a 100644
--- a/src/test/modules/test_misc/meson.build
+++ b/src/test/modules/test_misc/meson.build
@@ -16,6 +16,7 @@ tests += {
       't/005_timeouts.pl',
       't/006_signal_autovacuum.pl',
       't/007_catcache_inval.pl',
+      't/008_slots_in_single_user_mode.pl',
     ],
   },
 }
diff --git a/src/test/modules/test_misc/t/008_slots_in_single_user_mode.pl b/src/test/modules/test_misc/t/008_slots_in_single_user_mode.pl
new file mode 100644
index 000000000000..b3d9fe2fc332
--- /dev/null
+++ b/src/test/modules/test_misc/t/008_slots_in_single_user_mode.pl
@@ -0,0 +1,99 @@
+use strict;
+use warnings;
+use PostgreSQL::Test::Cluster;
+use PostgreSQL::Test::Utils;
+use Test::More;
+
+# Tests the slot manipulation in the single-user mode
+
+# Skip the whole thing on the windows platform
+if ($windows_os)
+{
+	plan skip_all => 'this test is not supported by this platform';
+}
+
+# Run passed commands in single-user mode. The return value from the command is
+# passed through.
+sub run_test_in_single_user_mode
+{
+	my ($node, $commands, $testname) = @_;
+
+	my $result = run_log(
+		[
+			'postgres', '--single', '-F',
+			'-c' => 'exit_on_error=true',
+			'-D' => $node->data_dir,
+			'postgres'
+		],
+		\$commands);
+
+	return $result;
+}
+
+# Wrapper function for run_test_in_single_user_mode. This would be used when
+# the input command succeeds.
+sub run_test_in_single_user_mode_success
+{
+	my ($node, $commands, $testname) = @_;
+
+	my $result = run_test_in_single_user_mode($node, $commands, $testname);
+
+	ok($result, $testname);
+}
+
+# Wrapper function for run_test_in_single_user_mode. This would be used when
+# the input command fails.
+sub run_test_in_single_user_mode_fail
+{
+	my ($node, $commands, $testname) = @_;
+
+	my $result = run_test_in_single_user_mode($node, $commands, $testname);
+
+	ok(!$result, $testname);
+}
+
+my $slotname = 'test_slot';
+
+# Initialize a node
+my $node = PostgreSQL::Test::Cluster->new('node');
+$node->init(allows_streaming => "logical");
+$node->start;
+
+# Define initial table
+$node->safe_psql(
+	'postgres', qq(
+CREATE TABLE foo (id int);
+SELECT pg_create_logical_replication_slot('$slotname', 'test_decoding');
+));
+
+# Stop the node to run and test in single-user mode
+$node->stop;
+
+run_test_in_single_user_mode_fail(
+	$node,
+	"SELECT pg_create_logical_replication_slot('another_slot', 'test_decoding')",
+	"replication slot cannot be created in single-user mode");
+
+run_test_in_single_user_mode_fail(
+	$node, qq(
+INSERT INTO foo VALUES (1);
+SELECT count(1) FROM pg_logical_slot_get_changes('$slotname', NULL, NULL);
+),
+	"logical decoding cannot be done in single-user mode");
+
+run_test_in_single_user_mode_fail(
+	$node,
+	"SELECT pg_replication_slot_advance('$slotname', pg_current_wal_lsn())",
+	"replication slot cannot be advanced in single-user mode");
+
+run_test_in_single_user_mode_fail(
+	$node,
+	"SELECT pg_copy_logical_replication_slot('$slotname', 'dest_slot')",
+	"replication slot cannot be copied in single-user mode");
+
+run_test_in_single_user_mode_success(
+	$node,
+	"SELECT pg_drop_replication_slot('$slotname')",
+	"replication slot can be dropped in single-user mode");
+
+done_testing();
diff --git a/src/test/recovery/meson.build b/src/test/recovery/meson.build
index 52993c32dbba..0b79896b61cf 100644
--- a/src/test/recovery/meson.build
+++ b/src/test/recovery/meson.build
@@ -56,7 +56,7 @@ tests += {
       't/045_archive_restartpoint.pl',
       't/046_checkpoint_logical_slot.pl',
       't/047_checkpoint_physical_slot.pl',
-      't/048_vacuum_horizon_floor.pl'
+      't/048_vacuum_horizon_floor.pl',
     ],
   },
 }