diff --git a/src/backend/replication/pgoutput/pgoutput.c b/src/backend/replication/pgoutput/pgoutput.c
index 92eb17049c3c..6f65c35c4f75 100644
--- a/src/backend/replication/pgoutput/pgoutput.c
+++ b/src/backend/replication/pgoutput/pgoutput.c
@@ -426,6 +426,19 @@ parse_output_parameters(List *options, PGOutputData *data)
 				errmsg("option \"%s\" missing", "publication_names"));
 }
 
+/*
+ * Memory context reset callback for clearing the cached relation info.
+ */
+static void
+cache_context_callback(void *arg)
+{
+	if (RelationSyncCache)
+	{
+		hash_destroy(RelationSyncCache);
+		RelationSyncCache = NULL;
+	}
+}
+
 /*
  * Initialize this plugin
  */
@@ -435,6 +448,7 @@ pgoutput_startup(LogicalDecodingContext *ctx, OutputPluginOptions *opt,
 {
 	PGOutputData *data = palloc0(sizeof(PGOutputData));
 	static bool publication_callback_registered = false;
+	MemoryContextCallback *mcallback;
 
 	/* Create our memory context for private allocations. */
 	data->context = AllocSetContextCreate(ctx->context,
@@ -449,6 +463,10 @@ pgoutput_startup(LogicalDecodingContext *ctx, OutputPluginOptions *opt,
 										 "logical replication publication list context",
 										 ALLOCSET_SMALL_SIZES);
 
+	mcallback = palloc0(sizeof(MemoryContextCallback));
+	mcallback->func = cache_context_callback;
+	MemoryContextRegisterResetCallback(data->cachectx, mcallback);
+
 	ctx->output_plugin_private = data;
 
 	/* This plugin uses binary protocol. */