Abstract
Background
Major stressful life events are known to predict depression onset, but relatively few studies have examined the interplay of daily stress and negative affect, particularly in clinical samples. Preliminary research has been inconclusive whether only current depression is characterized by amplified emotional reactivity to stress, or whether these patterns are equally strong in those with any history of depression.
Methods
Twenty-three participants with current major depression, 38 with remitted depression, and 43 with no history of depression completed 2 weeks of ecological momentary assessment to examine reactivity to perceived stress, negative daily events, and interpersonal versus noninterpersonal daily events.
Results
Currently depressed individuals demonstrated greater reactivity (i.e. greater increases in negative affect) in response to daily perceived stress, relative to previously depressed and never depressed individuals. Furthermore, while previously and never depressed individuals exhibited equal reactivity to interpersonal and noninterpersonal stress, currently depressed participants were particularly sensitive to interpersonal negative events.
Conclusions
These microlongitudinal results extend prior longitudinal evidence of the critical role of interpersonal stress in the course of major depression. The findings emphasize the importance of cognitive interventions that target negative interpretations of daily events.



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Notes
The terms “stress reactivity” and “emotional reactivity” have been used similarly in previous literature. We adopt the term stress reactivity here to emphasize the study’s focus on emotional responses to external daily stressors, negative events or other daily stress.
The difference in group sample size was due to the prevalence of current MDD, relative to remitted MDD or no history of MDD, within the larger project’s specific window for study entry, the first year of college.
Although gender differences were not a primary focus of the study, gender was examined as a possible moderator of stress reactivity. Gender did not moderate reactivity to negative events, interpersonal negative events, or noninterpersonal negative events, all ps > .145. Women did experience greater intensification of NA as perceived stress level increased, t(100) = 2.37, p = .020.
All stress reactivity models were re-analyzed to control for gender and baseline anxiety symptoms. There were no changes in the statistical significance of group differences in reactivity to perceived stress, to all negative events, to interpersonal events, or to noninterpersonal events. The only change in moderation results was that, compared with those with no history of depression, participants with current depression were no longer significantly more reactive to interpersonal versus noninterpersonal events, t(97) = 1.86, p = .067.
References
Allison, P. (2009). Fixed effects regression models. Thousand Oaks: Sage Publications.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Philadelphia: American Psychiatric Association.
Beck, A. T. (1983). Cognitive therapy of depression: New perspectives. In P. J. Clayton & J. E. Barrett (Eds.), Treatment of depression: Old controversies and new approaches (pp. 265–290). New York: Raven Press.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology,56, 893–897. https://doi.org/10.1037/0022-006X.56.6.893.
Beck, A. T., Rush, J., Shaw, B. F., & Emery, G. (1979). Cognitive therapy of depression. New York: Guilford Press.
Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck Depression Inventory (2nd ed.). San Antonio: The Psychological Corporation.
Bolger, N., & Laurenceau, J.-P. (2013). Intensive longitudinal methods: An introduction to diary and experience sampling research. New York: Guilford Press.
Bylsma, L. M., Morris, B. H., & Rottenberg, J. (2008). A meta-analysis of emotional reactivity in major depressive disorder. Clinical Psychology Review,28(4), 676–691. https://doi.org/10.1016/j.cpr.2007.10.001.
Bylsma, L. M., Taylor-Clift, A., & Rottenberg, J. (2011). Emotional reactivity to daily events in major and minor depression. Journal of Abnormal Psychology,120(1), 155–167. https://doi.org/10.1037/a0021662.
Connolly, S. L., & Alloy, L. B. (2017). Rumination interacts with life stress to predict depressive symptoms: An ecological momentary assessment study. Behaviour Research and Therapy,97, 86–95. https://doi.org/10.1016/j.brat.2017.07.006.
Downey, G., & Feldman, S. I. (1996). Implications of rejection sensitivity for intimate relationships. Journal of Personality and Social Psychology,70(6), 1327–1343. https://doi.org/10.1037/0022-3514.70.6.1327.
Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J. L., et al. (2013). Burden of depressive disorders by country, sex, age, and year: Findings from the Global Burden of Disease Study 2010. PLOS Medicine,10(11), e1001547. https://doi.org/10.1371/journal.pmed.1001547.
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2007). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). Biometrics Research, New York State Psychiatric Institute.
Froehlich, J., Chen, M. Y., Consolvo, S., Harrison, B., & Landay, J. A. (2007). MyExperience: A system for in situ tracing and capturing of user feedback on mobile phones. Paper presented at the ACM.
Glaser, J.-P., van Os, J., Portegijsc, P. J. M., & Myin-Germeys, I. (2006). Childhood trauma and emotional reactivity to daily life stress in adult frequent attenders of general practitioners. Journal of Psychosomatic Research,61, 229–236. https://doi.org/10.1016/j.jpsychores.2006.04.014.
Houben, M., Van Den Noortgate, W., & Kuppens, P. (2015). The relation between short-term emotion dynamics and psychological well-being: A meta-analysis. Psychological Bulletin,141(4), 901–930. https://doi.org/10.1037/a0038822.
Husky, M. M., Mazure, C. M., Maciejewski, P. K., & Swendsen, J. (2009). Past depression and gender interact to influence emotional reactivity to daily life stress. Cognitive Therapy and Research,33, 264–271. https://doi.org/10.1007/s10608-008-9212-z.
Johnson, E. I., Husky, M., Grondin, O., Mazure, C. M., Doron, J., & Swendsen, J. (2008). Mood trajectories following daily life events. Motivation and Emotion,32, 251–259. https://doi.org/10.1007/s11031-008-9106-0.
Kendler, K. S., Kuhn, J., & Prescott, C. A. (2004). The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. American Journal of Psychiatry,161(4), 631–636. https://doi.org/10.1176/appi.ajp.161.4.631.
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2000). Stressful life events and previous episodes in the etiology of major depression in women: An evaluation of the 'Kindling' hypothesis. American Journal of Psychiatry,157(8), 1243–1251. https://doi.org/10.1176/appi.ajp.157.8.1243.
Lamers, F., Swendsen, J., Cui, L., Husky, M., Johns, J., Zipunnikov, V., et al. (2018). Mood reactivity and affective dynamics in mood and anxiety disorders. Journal of Abnormal Psychology,127(7), 659–669. https://doi.org/10.1037/abn0000378.
Littman, A. J., White, E., Satia, J. A., Bowen, D. J., & Kristal, A. R. (2006). Reliability and validity of 2 single-item measures of psychosocial stress. Epidemiology,17, 398–403. https://doi.org/10.1097/01.ede.0000219721.89552.51.
Monroe, S. M., & Harkness, K. L. (2005). Life stress, the "kindling" hypothesis, and the recurrence of depression: Considerations from a life stress perspective. Psychological Review,112, 417–445. https://doi.org/10.1037/0033-295X.112.2.417.
Myin-Germeys, I., Peeters, F., Havermans, R., Nicolson, N. A., deVries, M. W., Delespaul, P., et al. (2003). Emotional reactivity to daily life stress in psychosis and affective disorder: An experience sampling study. Acta Psychiatrica Scandinavica,107, 124–131. https://doi.org/10.1034/j.1600-0447.2003.02025.x.
Nezlek, J. B., & Gable, S. L. (2001). Depression as a moderator of relationships between positive daily events and day-to-day psychological adjustment. Personality and Social Psychology Bulletin,27, 1692–1704. https://doi.org/10.1177/01461672012712012.
O'Neill, S. C., Cohen, L. H., Tolpin, L. H., & Gunthert, K. C. (2004). Affective reactivity to daily interpersonal stressors as a prospective predictor of depressive symptoms. Journal of Social and Clinical Psychology,23, 172–194. https://doi.org/10.1521/jscp.23.2.172.31015.
Parrish, B. P., Cohen, L. H., Gunthert, K. C., Butler, A. C., Laurenceau, J.-P., & Beck, J. S. (2009). Effects of cognitive therapy for depression on daily stress-related variables. Behaviour Reserach and Therapy,47, 444–448. https://doi.org/10.1016/j.brat.2009.02.005.
Parrish, B. P., Cohen, L. H., & Laurenceau, J.-P. (2011). Prospective relationship between negative affective reactivity to daily stress and depressive symptoms. Journal of Social and Clinical Psychology,30(3), 270–296. https://doi.org/10.1521/jscp.2011.30.3.270.
Peeters, F., Nicolson, N. A., Berkhof, J., Delespaul, P., & deVries, M. (2003). Effects of daily events on mood states in major depressive disorder. Journal of Abnormal Psychology,112(2), 203–211. https://doi.org/10.1037/0021-843X.112.2.203.
Preacher, K. J., Curran, P. J., & Bauer, D. J. (2006). Computational tools for probing interaction effects in multiple linear regression, multilevel modeling, and latent curve analysis. Journal of Educational and Behavioral Statistics,31, 437–448. https://doi.org/10.3102/10769986031004437.
Rohde, P., Lewinsohn, P. M., Klein, D. N., Seeley, J. R., & Gau, J. M. (2013). Key characteristics of major depressive disorder occurring in childhood, adolescence, emerging adulthood, and adulthood. Clinical Psychological Science,1(1), 41–53. https://doi.org/10.1177/2167702612457599.
Rottenberg, J. (2005). Mood and emotion in major depression. Current Directions in Psychological Science,14, 167–170. https://doi.org/10.1111/j.0963-7214.2005.00354.x.
Ruscio, A. M., Gentes, E. L., Jones, J. D., Hallion, L. S., Coleman, E. S., & Swendsen, J. (2015). Rumination predicts heightened responding to stressful life events in Major Depressive Disorder and Generalized Anxiety Disorder. Journal of Abnormal Psychology,124(1), 17–26. https://doi.org/10.1037/abn0000025.
Scollon, C. N., Kim-Prieto, C., & Diener, E. (2003). Experience sampling: Promises, pitfalls, strengths, and weaknesses. Jounal of Happiness Studies,4, 5–34. https://doi.org/10.1023/a:1023605205115.
Sheets, E. S., & Craighead, W. E. (2014). Comparing chronic interpersonal and noninterpersonal stress domains as predictors of depression recurrence in emerging adults. Behaviour Research and Therapy,63, 36–42. https://doi.org/10.1016/j.brat.2014.09.001.
Shrout, P. E., & Lane, S. P. (2012). Psychometrics. In M. R. Mehl & T. A. Conner (Eds.), Handbook of research methods for studying daily life (pp. 302–320). New York: Guilford Press.
Stroud, C. B., Davila, J., Hammen, C., & Vrshek-Schallhorn, S. (2011). Severe and nonsevere events in first onsets versus recurrences of depression: Evidence for stress sensitization. Journal of Abnormal Psychology,120(1), 142–154. https://doi.org/10.1037/a0021659.
Suls, J., Green, P., & Hillis, S. (1998). Emotional reactivity to everyday problems, affective inertia, and neuroticism. Personality and Social Psychology Bulletin,24, 127–136. https://doi.org/10.1177/0146167298242002.
Thompson, R. J., Mata, J., Jaeggi, S. M., Buschkuehl, M., Jonides, J., & Gotlib, I. H. (2012). The everyday emotional experience of adults with major depressive disorder: Examining emotional instability, inertia, and reactivity. Journal of Abnormal Psychology,121(4), 819–829. https://doi.org/10.1037/a0027978.
Trull, T. J., Lane, S. P., Koval, P., & Ebner-Priemer, U. W. (2015). Affective dynamics in psychopathology. Emotion Review,7(4), 355–361. https://doi.org/10.1177/1754073915590617.
van Eck, M., Nicolson, N. A., & Berkhof, J. (1998). Effects of stressful daily events on mood states: Relationship to global perceived stress. Journal of Personality and Social Psychology,75(6), 1572–1585. https://doi.org/10.1037/0022-3514.75.6.1572.
Vrshek-Schallhorn, S., Mineka, S., Zinbarg, R. E., Craske, M. G., Griffith, J. W., Sutton, J., et al. (2014). Refining the candidate environment: Interpersonal stress, the serotonin transporter polymorphism, and gene-environment interactions in major depression. Clinical Psychological Science,2(3), 235–248. https://doi.org/10.1177/2167702613499329.
Vrshek-Schallhorn, S., Stroud, C. B., Mineka, S., Hammen, C., Zinbarg, R. E., Wolitzky-Taylor, K., et al. (2015). Chronic and episodic interpesonal stress as statistically unique predictors of depression in two samples of emerging adults. Journal of Abnormal Psychology,124(4), 918–932. https://doi.org/10.1037/abn0000088.
Watson, D., & Clark, L. A. (1999). The PANAS-X: Manual for the positive and negative affect schedule—expanded form. Retrieved from https://www.psychology.uiowa.edu/Faculty/Watson/PANAS-X.pdf.
Wenze, S. J., Gunthert, K. C., Forand, N. R., & Laurenceau, J.-P. (2009). The influence of dysphoria on reactivity to naturalistic fluctuations in anger. Journal of Personality,77(3), 795–824. https://doi.org/10.1111/j.1467-6494.2009.00565.x.
Wichers, M. (2014). The dynamic nature of depression: A new micro-level perspective of mental disorder that meets current challenges. Psychological Medicine,44, 1349–1360. https://doi.org/10.1017/S0033291713001979.
Wichers, M. C., Barge-Schaapveld, D. Q. C. M., Nicolson, N. A., Peeters, F., deVries, M., Mengelers, R., et al. (2009a). Reduced stress-sensitivity or increased reward experience: The psychological mechanism of response to antidepressant medication. Neuropsychopharmacology,34, 923–931. https://doi.org/10.1038/npp.2008.66.
Wichers, M., Geschwind, N., Jacobs, N., Kenis, G., Peeters, F., Derom, C., et al. (2009b). Transition from stress sensitivity to a depressive state: Longitudinal twin study. The British Journal of Psychiatry,195, 498–503. https://doi.org/10.1192/bjp.bp.108.056853.
Wichers, M., Schrijvers, D., Geschwind, N., Jacobs, N., Myin-Germeys, I., Thiery, E., et al. (2009c). Mechanisms of gene–environment interactions in depression: Evidence that genes potentiate multiple sources of adversity. Psychological Medicine,39, 1077–1086. https://doi.org/10.1017/S0033291708004388.
Acknowledgements
This research was supported in part by Colby College Social Science Grant 01.2215. The authors express their appreciation to Rhiannon Archer, Jessica Blais, Shelley Kind, Monica Li, Kira Novak, Kelsey Park, Mariah Smith-Dutton, Stephanie Sienkiewicz, and Meredith Zakon who assisted in data collection.
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Erin S. Sheets and Michael F. Armey declare that they have no conflicts of interest.
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Sheets, E.S., Armey, M.F. Daily Interpersonal and Noninterpersonal Stress Reactivity in Current and Remitted Depression. Cogn Ther Res 44, 774–787 (2020). https://doi.org/10.1007/s10608-020-10096-2
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DOI: https://doi.org/10.1007/s10608-020-10096-2