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You’re Probably Not an Exercise “Non-Responder”

6 min readSep 27, 2026

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Photo by Derek Owens on Unsplash

It is easy to blame genetics when progress slows down.

You train for weeks. Maybe months. You look in the mirror, step on the scale, or compare your strength numbers and think:

Maybe I just don’t respond to exercise.

Genetics absolutely influence how quickly people build muscle, gain strength, recover, and adapt to training.

But the evidence suggests something important:

True exercise non-responders appear to be rare.

For most people, stalled progress is more likely to reflect the training program, consistency, recovery, nutrition, or exercise dose than an inability to build muscle.

And that is good news-because those are things you can change.

Genetics Matter, But They Are Not Destiny

Researchers recently examined more than 315,000 locations in the genome looking for genetic variants associated with muscle growth.

Only one significant candidate emerged.

That does not mean genetics are irrelevant.

Twin studies suggest a meaningful portion of exercise response is heritable, with estimates often ranging widely depending on the trait being measured.

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Drew Brennan
Drew Brennan

Written by Drew Brennan

Hi, my name is Drew, I am nothing special, and an everyday hard-working person who chose to make some small, but healthy changes in my life that may help you.