reiterating AJH
— 2001
Evidence has been accumulating for several years that protecting the endothelium is key to reducing CV risk.
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Endothelial dysfunction results in reduced compliance, or increased arterial stiffness, particularly in the smaller arteries.
the damage to the endothelium results in reduced secretion of nitric oxide, which influences smooth muscle growth, migration, and contraction, as well as influencing inflammation and clotting.
Arterial compliance can be measured by several techniques, most of which are invasive or otherwise not clinically appropriate.
Pulse contour analysis is a newly developed noninvasive method that allows for easy, in-office measurement of arterial elasticity to identify patients at risk for CV events before disease becomes clinically apparent.






