For Complete Article: http://www.annexpublishers.com/full-text/JNND/2301/Stability-Analysis-of-Human-Islet-Amyloid-Polypeptide-and-Its-Mutated-Oligomeric-Forms.php

13α(21)-Epoxyeurycomanone (EP) and eurycomanone (EN), the polar quassinoids of Eurycoma longifolia extract (TAF2) formulated as a lipid-based solid dispersion (TAF2-SD) to increase sperm count for oligospermic infertility, displayed improvement of oral pharmacokinetics and bioavailability in rats over the non-formulated TAF2 extract. The plasma concentration-time curves of the quassinoids in both preparations displayed double-peak phenomenon, similarly observed in BCS Class 3 drugs that are highly hydrophilic and of low phospholipid membrane permeability, which therefore prompted investigation of the contributing factors.

For Complete Details: http://www.annexpublishers.com/full-text/JBS/1105/Investigating-the-Double-Peak-Phenomenon-in-Oral-Pharmacokinetics-of-Eurycoma-Longifolia-quassinoids-in-Lipid-Based-Solid-Dispersion.php

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers. XPS analysis of the Ti2p core level region and Raman spectroscopy measurements show that oxide layers grown in sulphuric acid are characterised by a better defined oxidation state of titanium and by a higher content in anatase crystalline phase. XPS measurements indicate that oxidation in phosphoric acid solution produces oxide layers with two components of stoichiometric oxide and with the presence of phosphate inclusions which can be interesting in view of biomedical applications.

For Complete Article: http://www.annexpublishers.com/full-text/JMSN/s106/Anodic-Oxidation-of-Titanium-in-Sulphuric-Acid-and-Phosphoric-Acid-Electrolytes.php

Background: Excessive exposure to club drug gamma-hydroxybutyric acid (GHB) would cause cognitive dysfunction in which impaired Ca2+-mediated neuroplasticity in hippocampus may play an essential role in the pathogenesis of this deficiency. Considering melatonin is positive for neuroplastic regulation, the present study aims to determine whether melatonin would exert a neuro-protective effect on cognitive function following GHB.

Materials and Methods: Adolescent rats subjected to ten days of GHB (500 mg/kg) and received 10 or 100 mg/kg of melatonin were processed for time-of-flight secondary ion mass spectrometry (TOF-SIMS), quantitative immunohistochemistry, biochemical and radiographic assay, together with Morris water maze to analyze the ionic, neurochemical, bio-energetic, and behavioral effects of melatonin on GHB-induced cognitive dysfunction, respectively.

For Remaining Article: http://www.annexpublishers.com/full-text/JCBH/1102/Melatonin-Effectively-Preserves-Cognitive-Function-in-Club-Drug-Intoxicated-Rats.php

Objective: To determine the parameters of the sacrococcygeal teratoma (SCT) in a developing community

Study Design: An epidemiologic data pool was formed from cases of SCT submitted as surgical specimens to a Reference Pathology Laboratory serving the Igbo Ethnic Group in South-Eastern Nigeria.

Results: In all, 18 neonates were diagnosed with SCT. Females preponderated (83%). The patients were presented at birth immediately or within a few weeks. The maximum dimension averaged 8.7 cm. Only 2 cases were delivered by cesarean section. A twin was delivered healthy while the other twin was a still-born. There was no associated anomaly or malignancy. Three cases exhibited striking predominance, namely, isolated cartilage bars, psammoma bodies, and longish stretch of bowel mucosa and muscularis complete with nerve plexuses. In this community, prenatal sonography was not used.

For Remaining Article: http://www.annexpublishers.com/full-text/JCRS/3501/Sacrococcygeal-Teratoma-in-a-Developing-Community.php

Background: Increased inflammatory cytokines, C-reactive protein (CRP) and prothrombotic parameters are potential markers of cardiovascular risks in childhood obesity.

Objectives: We investigated whether a statin treatment can reverse these early cardiovascular risk indicators. The primary outcome was the effect of sixteen weeks of statins on the inflammatory cytokines, CRP and the pro-thrombotic state in obese adolescents.

Methods: This randomized controlled double-blind study conducted at the University Hospital of Geneva included 28 obese adolescents aged 12–16 years. Subjects received either placebo (P) or atorvastatin (A) for sixteen weeks. Levels of monocyte chemoattractant protein 1 (MCP-1), interleukin-6, interferon-γ-inducible protein, interleukin-10, interleukin-1 receptor antagonist and CRP were measured at baseline, after sixteen weeks and after one year. Coagulation parameters were evaluated by prothrombin time, activated partial thromboplastin time, fibrinogen levels and endogenous thrombin potential (ETP) at each visit.

For Remaining Article: http://www.annexpublishers.com/full-text/JPND/1103/Randomized-study-of-the-effects.php

We generated two hiPSC clones from a patient with sporadic late-onset alzheimer’s disease (AD-iPSCs), which expressed typical undifferentiated markers and passed standard pluripotency assays. Genome-wide microarray analysis revealed that AD-iPSCs were highly similar to control hiPSCs and hESCs, albeit with some noticeable differences in few genes, viz.: DNAJC15, GRPR, NAIP and SNORD116–18. Several other biomarkers were differentially expressed in AD-iPSC clones which have been implicated in memory impairment and AD. Furthermore, well characterized familial (APP, PSEN1, PSEN2) and non-familial (A2M, APOE, GAP43, MAOA, MPO, PLAT, PLAU, SORL1, SNCA) AD-associated genes exhibited different expression patterns but were largely reset upon reprogramming into a pluripotent state.

For Complete Research Article: http://www.annexpublishers.com/full-text/JSCCP/102/Human-Induced-Pluripotent-Stem-Cells-Derived-from-A-Patient-with-Sporadic-Alzheimers-Disease-Exhibit-Altered-Neuronal-Proliferative-Capacity.php

Immunodeficiency refers to failure of immune system to encounter infections by different microbial pathogens such as fungi, bacteria, viruses and protozoan. This is called acquired or secondary immunodeficiency syndrome (SIS). SID also arises due to other factors such as malnutrition, fatigue, use of immunosuppressants, chemotherapy, skin damage, pregnancy, aging, and recurrent infections. On contrary to it, the primary immunodeficiency syndromes (PIS) are genetic or inherited which makes an individual more susceptible any pathogenic infections. PIS may be recessive and is caused due to mutations in X chromosome.

For Complete Details: http://www.annexpublishers.com/full-text/JMC/1102/Immunodeficiency-and-Microbial-Infections.php

Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. Pioglitazone (PIO) is used for the treatment of type 2 diabetes mellitus and there is some evidence that it may improve ventricular function in diabetic patients. The effects of PIO on electrical conduction in the Goto-Kakizaki (GK) type 2 diabetic rat heart have been investigated. Transmitter devices were surgically implanted in GK and control rats aged 7 months. PIO at concentrations (2.5 to 20 mg/kg) was added to the drinking water. Animals received each concentration of PIO for 2 weeks. Bodyweight and blood glucose were measured periodically. The electrocardiogram was recorded throughout the study.

For Complete Article: http://www.annexpublishers.com/full-text/JCERC/301/Effects-of-Pioglitazone-on-the-Electrocardiogram-in-the-Goto-Kakizaki-Type-2-Diabetic-Rat-Heart.php

Background: Obesity increases the risk for variety of diseases which in turn, decreases the overall lifespan in both men and women. Though the cardiovascular risks of obesity are widely acknowledged, less often identified is the relationship between obesity and renal function.

Aim: To study the relationship between abdominal obesity and micro-albuminuria in elderly subjects.

Methods: A cross sectional study was conducted on 200 elderly subjects, aged ≥ 60 years. Subjects were recruited from both Geriatrics and Gerontology department and Internal medicine at Ain Shams University hospital, Cairo, Egypt. All patients had anthropometric measurements done including weight, height, body mass index, waist circumference, hip circumference and waist hip ratio, also assessment of blood pressure and albumin/creatinine ratio in urine.

For Remaining Article: http://www.annexpublishers.com/full-text/JOO/1202/Study-of-the-Relationship-between-Abdominal-Obesity-and-Micro-Albuminuria-in-Elderly.php