An Nguyen·6d agoThe 9.5-Megadalton Barrel: Inside Anthropic’s 3D Bacterial Vault DiscoveryBy An Nguyen — November 5, 2026
Venkatesh Manikantan·Jul 24From a Dusty Thesis to a Live API: Predicting an Enzyme’s Optimum Temperature from Sequence AloneYears later, I went back to my master’s thesis, where I taught a machine to read a protein sequence and guess the temperature it likes…
Neoncorte Bio·Jul 23In 2018, Frances Arnold won a Nobel Prize for engineering an enzyme to perform a completely…Today, we use AI “zero-shot fitness scores” (like the map below) to hunt for these breakthroughs. The AI predicts if a mutation is good or…
Engin Yapici·Jun 16PPIFlow: Picomolar Binder Design and the Limits of the BLI DataChangping Laboratory’s flow-matching pipeline reports picomolar affinities for six of seven mini-binder targets, all measured by BLI.
Engin Yapici·Feb 24Germinal: Open-Source Nanobody Design With Epitope Evidence and Some Unresolved GapsStanford and Arc Institute’s pipeline designs nanobodies against specified epitopes, testing only 43–101 candidates per target.
Engin Yapici·Jan 20Origin-1: Absci’s De Novo Antibody Design PlatformMicromolar hits with structural validation but therapeutic gaps.
Allu Vamsi Pavan Kumar·Jan 18The Evolution of RFdiffusion: From Structural Generation to Atomic-Resolution Molecular DesignProtein design has historically been constrained by a fundamental mismatch: we design at the residue level, but biology operates at the…
Engin Yapici·Dec 30, 2025Low Immunogenicity in Human Panels? Examining Latent-X2’s EvidenceAnalyzing the immunogenicity assay quality and binding validation in the first AI antibody study to test human immune responses
Engin Yapici·Dec 16, 2025Analyzing BoltzGen: MIT’s Multi-Target Binder Design ModelMIT released BoltzGen for computational binder design in collaboration with multiple academic labs and Adaptyv Bio*. The model handles…A response icon2A response icon2
