A patient with three different autoimmune diseases has entered complete remission after undergoing an experimental treatment that effectively reset her immune system.
Under Anne Hidalgo – mayor for 12 years until last week – the French capital added bike lanes, cut traffic and reclaimed public space, but not without resistance
A new gene therapy is giving people born deaf the chance to hear, often within just weeks. In a small but groundbreaking study, researchers delivered a working copy of a key hearing gene directly into the inner ear using a single injection. All ten patients, ranging from young children to adults, experienced improved hearing, with some showing rapid gains in just one month.
The human eye is like an immunological fortress, with its ability to exclude unwanted intruders a boon when preventing infection but a burden when trying to deliver vital medicines. Researchers in China have now turned to an unusual source—pig semen—to develop eye drops that can deliver cancer drugs to the back of the eye.
It is proposed that happiness be classified as a psychiatric disorder and be included in future editions of the major diagnostic manuals under the new name: major affective disorder, pleasant type. In a review of the relevant literature it is shown that happiness is statistically abnormal, consists of a discrete cluster of symptoms, is associated with a range of cognitive abnormalities, and probably reflects the abnormal functioning of the central nervous system. One possible objection to this proposal remains–that happiness is not negatively valued. However, this objection is dismissed as scientifically irrelevant.
But Khomeini and his close aides secretly engaged with Washington before and after he came to power following the Islamic Revolution in 1979, according to U.S. documents that have been declassified in recent years.
It was previously known that Ruhollah Khomeini, the charismatic leader of the Iranian revolution, had exchanged some messages with the US through an intermediary while living in exile in Paris. But new documents seen by the BBC’s Persian service show he went to a great lengths to ensure the Americans would not jeopardise his plans to return to Iran – and even personally wrote to US officials.
Indian studio Sanjay Puri Architects dreamed up plans for a university that are quite unlike the usual imposing structures that immediately come to mind. It’s a marvel from every angle, and especially so when you look at the roof.
Ham radio operators may be familiar with slow-scan television (SSTV) where an image is sent out over the airwaves to be received, decoded, and displayed on a computer monitor by other radio operators. It’s a niche mode that isn’t as popular as modern digital modes like FT8, but it still has its proponents. SSTV isn’t only confined to the radio, though. [BLANCHARD Jordan] used this encoding method to store digital images on a cassette tape in a custom-built tape deck for future playback and viewing.
The Church League of America, a right wing anti-communist research and advocacy group, collected these research files from other creators with a similar political outlook and professional activities: American Business Consultants Inc., the Wackenhut Corporation, and Karl Baarslag. All of these creators had connections to the intelligence agencies of the United States government, kept detailed research files on individuals and organizations, and were part of a right-wing research and information network that monitored Communists and other perceived threats to their interpretation of the American way of life.
The Central Intelligence Agency, directly violating its charter, conducted a massive, illegal domestic intelligence operation during the Nixon Administration against the antiwar movement and other dissident groups in the United States, according to well‐placed Government sources.
What if, though, “selves” are present in those very cells, ahead of the point at which they merge to form a greater whole? It might sound outlandish, but biological simulations are indicating that those minuscule units of life, which we usually think about as passive machines – cogs blindly governed by the laws of physics – have their own goals and display agency. Surprisingly, even simple networks of biomolecules appear to display some degree of a self, a revelation that could lead to novel ways of treating health conditions with far fewer side effects.
The longer I live, the more I notice with what fundamental imprecision emotions present themselves to us. The most profound grief can mingle with a sense of freedom, even relief; the greatest hope might be entangled with a sense of doom; and that dreaded thing coming to fruition might release us, however momentarily, from the burden of anticipating it. So, we might be tormented in one way and consoled in another through the process of grief, which is far more mysterious than we tend to give it credit for.
The salacious details of the Epstein Files have obscured the fact that they are also basically The Panama Papers II, revealing the sleazy economic machinations of the Epstein/Trump “unaccountable class”.
Came across this article a while back, and its a really interesting read. Since today is MLK day it seems like an appropriate day to share this. It’s an especially important moment in history to remember and honor an American patriot who refused to be silent even when he became the target of a man who abused his powerful position in the federal government while hiding behind lies about protecting liberty and justice.
The premier destination for Resume-Driven Development, Over-Engineering, and Resume-Padding. Why build simple solutions when you can build a distributed monolith?
A treatment that blocks an age-related protein restored cartilage in aging and injured joints by reprogramming existing cells rather than using stem cells.
This is a screen recording of a 60 Minutes segment about the Centro de Confinamiento del Terrorismo (CECOT) prison in El Salvador, which was intended to be aired December 22, 2025 but was pulled last minute for unclear reasons. Despite being pulled, it aired on Global-TV in Canada anyway.
Unidentified lights appeared above Kyushu’s Genkai Nuclear Power Station. A possible drone intrusion was suspected, but no visual record was captured by the plant’s security system. Experts say the incident reveals a weakness in aerial security. Globally, drone intrusions into key facilities are occurring with increasing frequency. For instance, at the Kori Nuclear Power Plant in South Korea, about 60 percent of incidents remain untraced. As drone technology continues to advance, how should Japan and the international community respond?
The human body naturally creates small amounts of hydrogen sulfide to help regulate functions throughout the body, from cell metabolism to blood vessel dilation. The rapidly burgeoning field of gasotransmission shows that gases are major cellular messenger molecules, with particular importance in the brain. However, unlike conventional neurotransmitters, gases can’t be stored in vesicles. Thus, gases act through very different mechanisms to rapidly facilitate cellular messaging. In the case of hydrogen sulfide, this entails the modification of target proteins by a process called chemical sulfhydration, which modulates their activity, says Solomon Snyder, D.Phil., D.Sc., M.D., professor of neuroscience at the Johns Hopkins University School of Medicine and co-corresponding author on the study.
You’ve probably never heard of the overclass, which is just how its members like it; they have a lot to answer for. They are the people who put Jim Carrey on magazine covers, who renamed blue-green “teal” and keep loaning money to Donald Trump–not out of any sinister conspiracy to ruin the country but because, well, it’s their job. As “professionals” and “managers” they lay claim to an increasing share of the national income, but they wind up spending most of it at mirror-walled restaurants where they have to eat $10 arugula salads. They’re famous for having opinions, but it’s hard to know what these are, since they never call talk-radio shows. If they didn’t exist we’d have to invent them, because otherwise we’d have no answer to the question, whatever happened to all those Yuppies we used to see running around, anyway?
It’s been a productive year for Carlo Ratti Associati, an Italian architectural firm known for blending man-made construction with natural environments. The company recently unveiled a sophisticated mountain shelter that will soon find its permanent location in the Italian Alps. Now, CRA has collaborated with American creative studio Höweler + Yoon and Italian steel construction company Cimolai on a new experiment. The result of their five-month effort is a 400-square-meter (4,306-sq-ft) floating plaza – AquaPraça.
Collins Dictionary has named “vibe coding” its 2025 word of the year – a term coined by Andrej Karpathy for when a user makes an app or website by describing it to AI rather than writing programming code manually. The term, which is confusingly made up of two words, was “one of 10 words on a shortlist to reflect the mood, language and preoccupations of 2025,” reports the BBC.
Link without paywall: https://removepaywalls.com/4/https://thedailyrecord.com/2020/06/18/how-emergent-biosolutions-became-the-us-go-to-biodefense-contractor/
Link without paywall: https://removepaywalls.com/4/https://www.americanbanker.com/opinion/the-next-epstein-is-probably-already-here-hidden-in-plain-sight
Just came across this interview of Epstein regarding his interest in Bitcoin circa 2017. What’s most interesting is that it seems Epstein may have been heavily influenced by Peter Thiel around the time he gave the interview.
Nelson: I wrote Shadow Network out of a sense of civic duty. I observed some trends in our national life that were anti-democratic and detrimental to our public welfare. I’m deeply concerned by the epidemic of gun violence in our schools, the growing disdain for science and fact-based reporting, and, gravest of all, the campaigns against climate science and environmental protections.
Not so much an article, as just a list of things his estate auctioned off, including clothes, furniture, awards and more. To me, this is fascinating and quite the rathole to go down.
US scientists testing the technique say it could help people overcome infertility and potentially allow same-sex couples to have a genetically related child.
“The speed at which this doomed stellar system is lurching wildly, likely due to the extreme brightness, is a frantic sign of its imminent, violent end.”
For the first time, scientists have discovered that smell and taste are inseparable much earlier in the brain than we thought. New research shows that odors can actually be coded as tastes in the brain’s primary taste cortex, overturning decades of assumptions about how flavor is built.
Used heavily in early medicine and at times for opposing aims, the pomegranate shows a marked versatility in its cultural connotations and connections.
Mice turning tiny steering wheels to move shapes on a screen have helped scientists produce the first brain-wide map of decision-making at single-cell resolution in a mammal. In two Nature papers published Sept. 3, an international team of 22 groups, co-led by three Princeton University neuroscience labs, charted the activity of more than 600,000 neurons as mice performed a decision-making task. The resulting dataset offers an unprecedented view of how distributed neural networks work together across the brain to guide behavior.
Wouldn’t it be great if the plants in your home could do more than just sit there looking pretty? Researchers at South China Agricultural University in the city of Guangzhou have found a way to upgrade them into soft glowing night lights in a range of hues, with the use of nanoparticles.
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