In this Journal Club, Adrianna San Roman describes a 1997 study by Rao et al. that exemplifies how thorough measuring of genotypes and phenotypes in a variable human cohort is instrumental to identifying the genetic basis of clinical phenotypes.

Ian Barnes discusses how a seminal paper by Krings et al. invoked renewed interest in the field of ancient DNA, inspiring both researchers and the wider public.

In this Journal Club, Maanasa Raghavan recalls a 1984 paper by Higuchi et al. that demonstrated how sequencing ancient DNA provides unique evolutionary insights.

In this Journal Club, Minoli Perera reflects on a 2005 sequencing study by Cohen et al., who discovered two common loss-of-function mutations with large effects on plasma cholesterol levels thanks to the inclusion of African American study participants.

Despite their immense potential, gene and cell therapies that target rare diseases are at risk of market withdrawal, owing to several challenges. The authors describe these hurdles and call for innovative measures to improve the economic sustainability of gene and cell therapies after regulatory approval.

Biologically informed neural networks promise to lead to more explainable, data-driven discoveries in genomics, drug development and precision medicine. Selby et al. highlight emerging opportunities, as well as challenges that will need to be overcome to enable their wider adoption.