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Joined 3 years ago
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Cake day: July 5th, 2023

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  • Ok, so the study was specifically targeting a genetic form of deafness linked to mutations in a gene called OTOF. These mutations prevent the body from producing enough of the protein otoferlin, which is essential for sending sound signals from the inner ear to the brain.

    researchers used a synthetic adeno-associated virus (AAV) to deliver a working version of the OTOF gene directly into the inner ear.

    Super cool! And now they’re targeting other genetic forms of deafness hoping to deliver similar results. Neat!

    “OTOF is just the beginning,” says Dr. Duan. “We and other researchers are expanding our work to other, more common genes that cause deafness, such as GJB2 and TMC1. These are more complicated to treat, but animal studies have so far returned promising results. We are confident that patients with different kinds of genetic deafness will one day be able to receive treatment.”




  • You’re allowed to shoot unarmed soldiers you say?

    [p]ersons taking no active part in the hostilities, including members of armed forces who have laid down their arms and those placed hors de combat by sickness, wounds, detention, or any other cause, shall in all circumstances be treated humanely, without any adverse distinction founded on race, colour, religion or faith, sex, birth or wealth, or any other similar criteria. To this end, the following acts are and shall remain prohibited at any time and in any place whatsoever with respect to the above-mentioned persons: (a) violence to life and person,-

    Dang sure sounds like the unarmed soldiers 2000 miles from the illegal war were hors de combat to me, but what the fuck do I know? I’m just someone who values human life above the whims of a pedophile traitor but I assume you’re not bothered by such concerns?






  • I can tell you didn’t read the article.

    The IRIS Dena was taking part in an international fleet review in the Bay of Bengal. Comprised of seventy-five foreign delegations, including the United States, Germany, Japan, and Australia. The theme of the joint exercise: “United by Oceans.”

    As a precondition of its participation in the fleet review and the Milan 2026 exercises in India, the IRIS Dena was unarmed. When it met what Secretary Hegseth boastfully called its “quiet death,” the IRIS Dena was essentially an off-duty vessel, traveling home from a ceremonial voyage on ocean waters that were declared, in 1971 by the UN General Assembly, a zone of peace.

    The United States knew the IRIS Dena was unarmed, and it knew its approximate whereabouts, as it participated in the same exercise.

    The same Los Angeles–class nuclear-powered attack submarine that sank the Dena, the USS Charlotte, had participated in the same Fleet review. They knew it was unarmed. They followed the unarmed ship from the international unity review, and then sank the vessel in open water, 2000 miles from the illegal war being waged by drumpf and his pedophile allies.

    This is just another war crime in a multitude of them. Every single person in this administration should hang.


  • The problem lies in the top 1% using their shares of a company as their personal bank account. They can use these shares as collateral for a loan, bypassing all income tax. If accountant can figure out how a billionaire can avoid paying taxes on the entirety of their massive yearly income, then others can figure out how to tax it properly. If you’re income is more than 70% this weird untaxable thing, then congrats, we gon’ tax it now.


  • jpreston2005toMicroblog MemesImposter syndrome
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    3 days ago

    I know enough that I don’t go around complaining about barely scraping by with $100k a year salary. You’d think that’d be enough to buy you some common sense, but here we are. 🤷‍♂️

    You’re just doing better than 90% or all people in the United states, and 99% of all the people in the world, but hey

    I SHOULD JUST TOUCH SOME GRASS


  • jpreston2005toMicroblog MemesImposter syndrome
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    3 days ago

    wow so you’re saying that it would take some other astronomical expense to make $100k a year “barely scraping by.” Gotchu, so we’re on the same page!

    coming on here and crying about only making $100k a year and you want me to feel sorry for him? Oh my bad, I didn’t realize this was absurd request day. Lemme just spare some mental energy and empathy for the poor soul barely scraping by on $100k a year salary 🙄 👍


  • jpreston2005toMicroblog MemesImposter syndrome
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    11 days ago

    No, I’m suggesting that it’s insanely expensive to raise kids in the United States, because it 100% is. It’s morally repugnant, ethically evil, and absolute bullshit, but it’s the truth.

    Having kids in the US (as in multiple children), you need both parents working, or one partner making at least $100k per year.

    Coming on here and pretending that 100k is barely enough for you is some performative bullshit, unless you give the full story. My wife doesn’t work, we have 3 kids, we live in a really nice part of town… etc. etc. These are hugely expensive and unnecessary things to do. Live in a worse house in a worse part of town while your wife works, and that income sets you up like a godamned king.

    My cousins live in bumfuck kentucky, and raise children on FAR less. Go tell them you’re having such a hard time “scraping by” with your pitiful 100k+ salary 🙄


  • Yo I need a new Boy Dinner community. Every time I see one of those Girl Dinner posts, always a tiny lil plate with like, a slice of cheese, a crouton and three grapes… I’m just like, who are you performing for? What is this post meant to suggest? WTF is this fictitious diet you’re pretending to have??





  • jpreston2005toMicroblog MemesImposter syndrome
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    11 days ago

    Well shit there you go, kids is the answer. You can’t say “I make over 100K a year and I’m barely scraping by” and then not mention you have done -the single most expensive thing you could have done-

    100k is so more than enough. Is it enough to own a house and raise kids while the other spouse stays at home? Also yes, just less so.

    Your take is delusional, my dude, and reeks of unacknowledged privilege.


  • jpreston2005toMicroblog MemesImposter syndrome
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    11 days ago

    I was at a birthday party the other night, and I spoke in passing about how I had performed a brand new comedy set the previous night (I’m an amateur stand-up comedian). I’ve been doing it for a few years and I’ve gotten pretty good at it, to the point I don’t even try out my new stuff at lesser mics, I know what’s funny, I write a brand new set every couple of weeks and then go perform it at the one good show my city consistently has. I’m proud of my art, and like I said, I’ve gotten pretty good at it. like, I consistently have to slow down my set so people can finish laughing at the previous jokes.

    Well at the birthday party were a couple of other guys that fancied themselves comedians, but only one of them had ever actually done it, and from what I heard, that single time wasn’t the best. It’s a karaoke party, so these guys grab the mic, and start reading jokes from their phone… and… Yeah, just lame, hacky, border-line offensive material. Like one guy just straight up googled a joke website and was reading from it. Then the next guy went on to perform and… Man I recognized half the jokes from reddit 🫥 But hey, his girlfriend was laughing so…

    Anyway, they wanted me to go up, but… man, a party of like 6 people in a living room isn’t a stand-up venue. Every comedian knows this, stand-up doesn’t work outside of stand-up. Like, some stuff can, but for the most part, it just doesn’t. Especially for my comedy, I use different mannerisms and affectations to lure the crowd into thinking I’m A, then hit’em with B. So I’m essentially playing a character. If you already know who I am, then it doesn’t work as well. I did not perform for them.

    I dunno, All that to say sometimes I feel like I’m a dummy who over the course of three years of regular stand-up has only amassed around 45 minutes of solid jokes… but then I saw these guys, and… I dunno man, I think I might be really fucking funny. I’ll have a chance to prove it to them soon, as I’m inching closer and closer to recording a full special. Hopefully it goes well, or else the real joke will be me writing this circlejerk fluff piece immediately before crashing/burning