Papercut

Drenick et al. demonstrated that, after a 2-month fast in obese subjects, insulin stimulation failed to precipitate hypoglycemic reactions with plasma glucose as low as 9 mg/dl (0.5 mM) [25].

This is really important, when fully fat adapted the human body can exist with massively low blood glucose levels. Well beyond what would be considered a hypoglycemic emergency. This isn’t relevant for people just doing ketosis for general health, but it is illustrative of the power of fat adaption. This paper calls it out because its part of a cancer treatment protocol where they create hypoglycemic states in patients.

During prolonged fasting, blood glucose levels below 30 mg/dL (1.70 mM) have been sustained continuously for several months without adverse effects [22, 23].

Ahh! let’s talk about ought!

Since humans store fat, one could see mechanistically we are setup to run on the energy we store: fat

When humans go more then 4 hours without eating glucose (skipping a meal, keto, fasting, or sleeping) they are running on fat, including the brain. If you want to prevent your brain from using fat you need to drip feed glucose all day (which some people try really hard to do), but when you sleep some of that fat will finally get to be used by the brain. One could reasonably argue the default energy of the human body is fat, hence why it’s used during sleep.

https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2016.00053/full#h7

Both short-term PET and arterio-venous difference studies in humans show that brain glucose consumption decreases as ketone availability to the brain increases. These results suggest that ketones are actually the preferred energy substrate for the brain because they enter the brain in proportion to their plasma concentration irrespective of glucose availability; if the energy needs of the brain are being increasingly met by ketones, glucose uptake decreases accordingly. This decrease in brain glucose uptake when both ketones and glucose are available supports the notion that ketones are the brain’s preferred fuel.

The body will use glucose when available, because glucose is so damaging to cells - glycation happens rapidly. As soon as any glucose elevations are seen in the blood stream insulin is immediately released to push glucose into fat cells and get blood glucose levels back to the low normal.

However, I’m open to being wrong: Why ‘ought’ the brain use glucose instead of fat?

Arne Høygaard, Studies on the Nutrition and Physio-Pathology of Eskimos, undertaken at Angmagssalik, East-Greenland, 1936–1937 - https://www.nb.no/items/c73c89a07af4f6285f497a212e56e92e

Need a Norway IP address, but the full book is online

9m27s:

french toast!

Sure, humans are lipvores we store fat we run on fat, stored fat is often seen as weight.

Regardless if a person is skinny, fat, or in between their brain can run on fat.

1h:02m -

The talk about WWII women gaining fat while their families were starving was heart breaking (around the 32m mark)

I’m not talking about your weight, I’m talking about the fuel source for the brain. The body runs on fat, the brain runs on fat. It can, when available, also use glucose - but the entire metabolic system tries to keep glucose levels low and consistent rather then spiked and high.

I did some poking into Dr Glandt’s publication history:

• 2025 — Myths and Facts Regarding Low-Carbohydrate Diets. Summary: review/opinion paper addressing common claims about low-carbohydrate and ketogenic diets. DOI: https://doi.org/10.3390/nu17061047

• 2024 — Use of a very low carbohydrate diet for prediabetes and type 2 diabetes: An audit. Summary: clinical audit of a very-low-carbohydrate ketogenic program for prediabetes and type 2 diabetes. DOI: https://doi.org/10.4102/jmh.v7i1.87

Starches and carbs feed the brain.

Turns into blood glucose, which the body can use in the brain, but works as hard as it possibly can to put into fat cells. The brain also runs perfectly well on fat, humans store fat not glucose for long term energy.

You need to be relatively healthy to do full range calisthenics. For people starting off at a deficit then weight training allows immediate muscle targeting while someone gets back into healthy range

If a single organization controls it but the architecture is over a large area then it’s distributed.

Would you say someone who uses cloud flare is using a decentralized architecture?

Oh no, step-peer! what are you doing?

Opsec is hard, and unforgiving.

You can’t claim to be decentralized and also extort people with a shutdown donation scheme in the same breath.

The decentralized private messaging app

If we are unable to reach our funding goal within this period, the Session Technology Foundation (STF) will be forced to shut down.

Both of these things can’t be true.

All the more reason to not let google ban side loading

This post, if taken seriously will also kill people.

Is your position that cancer is independent of metabolism?

FWIW: fruitarian is the opposite of a ketogenic metabolism - it floods the body with glucose that the cancer needs.

https://foundationformetaboliccancertherapies.com/publications/

Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle - https://doi.org/10.1016/j.molmet.2021.101389

They have some publications listed that I had missed!

Oh, this one is super interesting, i think it should be a full post after I finish reading it:

Provocative Question: Should Ketogenic Metabolic Therapy Become the Standard of Care for Glioblastoma? - doi - full text