RCTs - Protocols/Proposals (non-eHealth)

Interventions to Reduce Serum Per- and Poly-Fluoroalkyl Substances Levels, Improve Cardiovascular Risk Profiles, and Improve Epigenetic Age Acceleration in US Firefighters: Protocol for Randomized Controlled Trial

Reagan Conner, Cynthia Porter, Karen Lutrick, Shawn C Beitel, James Hollister, Olivia Healy, Krystal J Kern, Floris Wardenaar, John J Gulotta, Kepra Jack, Matthew Huentelman, Jefferey L Burgess, Melissa Furlong

JMIR Res Protoc 2025 (Apr 16); 14:e67120

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Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

Beth E Meyerson, Alissa Davis, Richard A Crosby, Linnea B Linde-Krieger, Benjamin R Brady, Gregory A Carter, Arlene N Mahoney, David Frank, Janet Rothers, Zhanette Coffee, Elana Deuble, Jonathon Ebert, Mary F Jablonsky, Marlena Juarez, Barbara Lee, Heather M Lorenz, Michael D Pava, Kristen Tinsely, Sana Yousaf

JMIR Res Protoc 2025 (Apr 15); 14:e69829

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Effect of Continuous Positive Airway Pressure or Positional Therapy Compared to Control for Treatment of Obstructive Sleep Apnea on the Development of Gestational Diabetes Mellitus in Pregnancy: Protocol for Feasibility Randomized Controlled Trial

Frances Clements, Hima Vedam, Yewon Chung, John Smoleniec, Colin Sullivan, Renuka Shanmugalingam, Annemarie Hennessy, Angela Makris

JMIR Res Protoc 2025 (Apr 11); 14:e51434

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Effectiveness of Stromal Vascular Fraction (SVF) and Platelet-Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Protocol for a Phase 3, Prospective, Randomized, Controlled, Multicenter Study (SPOST Study)

Adrien Schwitzguebel, David Andres Ramirez Cadavid, Tamara Da Silva, Pierre Decavel, Charles Benaim

JMIR Res Protoc 2025 (Apr 08); 14:e62659

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Effects and Safety of Press-Needle Therapy for Improving Visual Function and Eye Blood Circulation in Patients With Glaucoma With Controlled Intraocular Pressure: Study Protocol for a Multicenter Randomized Controlled Trial

Hongji Liu, Yan Dai, Ming Yu, Jian Zeng, Chao Wang, Sa Tan, Ming Xiong, Ran Zhang, Xuemeng Yu, Mingsong Shi, Xing Yan, Fengming Lai

JMIR Res Protoc 2025 (Apr 01); 14:e67737

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Evaluation of the Clinical Nursing Effects of a Traditional Chinese Medicine Nursing Program Based on Care Pathways for Patients With Type 2 Diabetes: Protocol for a Randomized Controlled Clinical Trial

Yanchun Zhao, Ting Huang, Yanli Chen, Songmei Li, Juan Zhao, Xu Han, Qing Ni, Ning Su

JMIR Res Protoc 2025 (Mar 31); 14:e58951

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Comparative Evaluation of Effectiveness of Standard of Care Alone and in Combination With Homoeopathic Treatment in COVID-19–Related Rhino-Orbito-Cerebral Mucormycosis (ROCM): Protocol for a Single Blind, Randomized Controlled Trial

Harleen Kaur, Jyoti Sachdeva, Ramesh Bawaskar, Twinkle Goyal

JMIR Res Protoc 2025 (Mar 19); 14:e57905

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Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan

JMIR Res Protoc 2025 (Mar 10); 14:e44027

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Evaluation of the Efficacy of the Traditional Chinese Medicine Formulation Ru-Yi-Jin-Huang-Saan on Colles Fracture After Surgery: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

Lien-Cheng Lin, Wei-Hsun Wang, Wei-Kai Chang, Jyun-Liang Gao, Ru-Chang Yang, Po-Chi Hsu, Lun-Chien Lo

JMIR Res Protoc 2025 (Mar 05); 14:e56849

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Auricular Acupressure Versus an Intermittent Low-Carbohydrate Diet in Children With Overweight or Obesity With Gastric-Heat and Dampness-Obstruction Syndrome: Protocol for a Randomized Controlled Trial

Wen Sun, Jingwei He, Wenqin Wang, Chen Lu, Yating Lin, Yalan Dou, Weili Yan, Jian Yu

JMIR Res Protoc 2025 (Mar 03); 14:e59856

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Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial

Hyeonsang Shin, Woohyun Seong, Yeonju Woo, Joo-Hee Kim, Kwang-Rak Park, Dong Hyuk Lee

JMIR Res Protoc 2025 (Feb 19); 14:e66838

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Effectiveness of Adaptation of a Resilience-Building Intervention Among Individuals With Adverse Childhood Experience: Protocol for a Randomized Controlled Trial

Jun Kiat, Mahadir Ahmad, Caryn Mei Hsien Chan, Satirah Zainalabidin, Michael Ungar, Ponnusamy Subramaniam

JMIR Res Protoc 2025 (Feb 12); 14:e56826

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Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial

Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

JMIR Res Protoc 2025 (Feb 10); 14:e56062

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ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial

Christian Burisch, Abhav Bellary, Frank Breuckmann, Jan Ehlers, Serge C Thal, Timur Sellmann, Daniel Gödde

JMIR Res Protoc 2025 (Feb 06); 14:e63887

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Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Trial

Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

JMIR Res Protoc 2025 (Feb 03); 14:e63063

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Impact of the Mediterranean Diet on Patients With Psoriasis: Protocol for a Randomized Controlled Trial

Javier Perez-Bootello, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Ruth Cova-Martin, Leticia Goni, Asuncion Ballester-Martinez, Pedro Jaen-Olasolo, Nehal Mehta, Joel M Gelfand, Miguel Angel Martinez-Gonzalez, Alvaro Gonzalez-Cantero

JMIR Res Protoc 2025 (Jan 29); 14:e64277

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Evaluating the Effectiveness of a Multimodal Psychotherapy Training Program for Medical Students in China: Protocol for a Randomized Controlled Trial

Tao Pei, Yinan Ding, Jinsong Tang, Yanhui Liao

JMIR Res Protoc 2025 (Jan 03); 14:e58037

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Improving Oral Health in Prisons (PriOH): Protocol for a Randomized Controlled Trial

Emilie Bryne, Kathrine Høyvik Bergum, William Gilje Gjedrem

JMIR Res Protoc 2024 (Dec 11); 13:e60817

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Remotely Delivered Video Interaction Guidance for Families of Children With an Intellectual Disability Referred to Specialist Mental Health Services: Protocol for a Feasibility Randomized Controlled Trial

Charmaine Kohn, Lauren Turner, Zhixing Yang, Michael Absoud, Angela Casbard, Manuel Gomes, Gemma Grant, Angela Hassiotis, Eilis Kennedy, Sophie Levitt, Rachel McNamara, Elizabeth Randell, Vasiliki Totsika

JMIR Res Protoc 2024 (Dec 05); 13:e54619

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Influence of Distraction Factors on Performance in Laparoscopic Surgery in Immersive Virtual Reality: Study Protocol of a Cross-Over Trial in Medical Students and Residents—DisLapVR

Laura Hanke, Richard Schulte, Christian Boedecker, Florentine Huettl, Patrick Saalfeld, Vuthea Chheang, Marlene Wessels, Christoph von Castell, Heiko Hecht, Christian Hansen, Hauke Lang, Tobias Huber

JMIR Res Protoc 2024 (Nov 05); 13:e59014

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